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KMID : 0378120020290020009
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Chungnam Medical Journal
2002 Volume.29 No. 2 p.9 ~ p.21
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A Noble Gene, Reg Ⅳ, Expressed in Human Gastric Cancer
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Kim Su-Ryoung
Seo Eun-Young
Lee Woong-Hee
Lee Jeung-Hoon
Lee Choong-Sik
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Abstract
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A search for the genes expressed only in gastric cancer may help to define molecular alterations or aid in diagnosis of gastric cancer. Recently, suppression subtractive hybridization (SSH) has been used as an effective technique for detection of differentially expressed genes. We discovered a noble gene which belongs to the Reg family in stomach cancer tissue using the SSH technique. We identified and named the Reg Ⅳ gene that is highly expressed only in gastric tumor tissue. The Reg family gene has a lot of functions of the growth factor and gene regulation. The cathepsin L-12 gene, which is known to exhibit increased expression in breast cancer and some inflammatory conditions, is also expressed in stomach cancer. Expressions were verified by reverse Northern blot analysis and Northern blot analysis. We expect these genes to be used as an important tool for the diagnosis and/or understanding of the pathogenesis of gastric cancer.
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KEYWORD
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Human gastric cancer, SSH, Reg Ⅳ, Cathepsin L-12
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